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IBSSure

IBSSure

$237.00 - Free Shipping

A simple and reliable tool for detecting IBS-D associated with Small Intestinal Bacterial Overgrowth (SIBO)

Description

- Blood Test

IBS is a commonly occurring collection of symptoms diagnosed in the world of gastroenterology. It is the most common GI disorder with worldwide prevalence rates ranging from 10-15%. There are between 2.4 and 3.5 million physician visits annually for IBS in the US. Recent research has shown that up to 84% of those with an IBS diagnosis test positive for a Small Intestinal Bacterial Overgrowth breath test.

Breath tests for Small Intestinal Bacterial Overgrowth can be very time consuming for patients, as well as inaccurate, due to many factors.

IBSSureTM is a simple blood test that detects two antibodies which are indicative of bacterial-pathogen-induced motility dysfunction, which can lead to increased incidence of SIBO.
CdtB toxins (cytolethal distending toxin B) are released by gastroenteritis-causing bacteria, against which antibodies are produced by the immune system. These antibodies interact with a protein, vinculin, present in the intestinal cell-lining matrix. This interaction compromises and impairs digestive motility. This pathological breakdown of the gastrointestinal motility complex is foundational to chronic SIBO development and recurrence and has been well-studied and documented.

IBSSure Sample Report

Markers Measured

  • Anti-CdtB IgG and IgA
  • Anti-vinculin IgG and IgA

Symptoms

WHAT IS SIBO?

  • Small intestinal bacterial overgrowth (SIBO) is defined as the presence of excessive bacteria in the small intestine
  • SIBO is frequently implicated as the cause of chronic diarrhea and malabsorption in addition to intestinal hyper-permeability
  • Patients with SIBO may also suffer from unintentional weight loss, nutritional deficiencies, and osteoporosis
  • A common misconception is that SIBO affects only a limited number of patients, such as those with an anatomic abnormality of the upper gastrointestinal (GI) tract or those with a motility disorder
  • SIBO may be more prevalent than previously thought. This apparent increase in prevalence may have occurred, in part, because readily available diagnostic tests have improved our ability to diagnose SIBO

Symptoms associated with SIBO

  • Abdominal pain/discomfort
  • Bloating
  • Abdominal distension
  • Diarrhea
  • Excessive gas
  • Fatigue, especially after meals
  • Brain fog
  • Vitamin and mineral deficiencies
  • Worsened symptoms when consuming carbohydrates and fibrous vegetables
  • Unexplained weight loss

About Test

Key Details

  • Sample collection must be performed by a phlebotomist any day Monday-Friday.
    • More information on scheduling a blood draw can be found HERE.
    • You may need to pay an additional fee for phlebotomy.
  • Review your kit - When you receive the test kit in the mail, review its contents, and read through the information provided with the kit.
  • Place frozen ice packs (if included with the kit) in the freezer for at least 24 hours prior to your appointment.
  • Scheduling your blood draw any day Monday-Friday.
    • Search for a "mobile phlebotomist" who will come to your home, or:
    • Locate a blood draw site HERE. Please note: Quest and LabCorp only draw for their own tests, not for Vibrant America tests.
    • If you are in a rural location, consider asking your doctor's office to draw for the kit, or, call your local hospital and ask if they offer this service.
    • You may need to pay an additional fee for phlebotomy.
    • Your test kit may come with more tubes than needed. Please have the phlebotomist check the collection instructions and your test requisition form to determine the correct tubes to draw. Your phlebotomist will know what to do with the tubes and instructions provided.
  • After the blood draw is collected, you are all done! Your phlebotomist will process, package and ship your completed kit for you.

What to bring to your appointment:

  • Completed Testing Release Form
  • Frozen ice packs
  • Full test kit with all contents and forms
  • Fasting is not required for your kit. Drink plenty of water.

Verify the kit contents, which typically includes:

  • Requisition form: lab orders needed for the phlebotomist to draw your samples. Confirm your information is correct on this form.
    • Since your kit has been prepaid, you do not need to fill in the payment information on any of these forms.
  • Testing Release Form: You must fill this out and return it with your samples
  • Tubes: these are specific to the samples the test requires and some may have extra reagents in the tubes (this is not condensation!)
  • Ice pack: if present, place in the freezer (you must bring these to the phlebotomy appointment)
  • Shipping materials: a biohazard bag for your samples & return shipping label
  • For return shipment tracking, take a picture of the shipping label if you'd like to track status of the kit; most labs can't provide this information once the kit is shipped
  • Draw instructions: for the phlebotomist to confirm the test specific instructions.

Preparation & Timing

  • Sample collection must be performed Monday-Friday only by a phlebotomist.
    • More information on scheduling a blood draw can be found HERE.
    • You can find a Vibrant America-partnered blood draw location HERE.
  • If you are currently taking (or have recently taken) any of the following medications, consult your healthcare provider regarding the timing of collection.
    • Steroids
    • Immunosuppressive medications
    • Biologic agents
    • Other immunomodulating medications
  • Hydrate the day prior to the test.
  • Freeze the provided ice packs for at least 24 hours prior to your blood draw.

Requisition & Payment

  • Your kit has been prepaid. You may need to pay an additional fee for phlebotomy.
  • Instructions on how to fill out your requisition can be found HERE.
    • Since you pre-paid for your tests, you do not need to fill in the payment information on any of these forms.
    • You must fill out the Testing Release Form (you can find this paper in the same place as your requisition form) and return it with your samples.

The Vibrant Experience

Vibrant America is a leading science and technology company delivering life-transforming laboratory services using an integrated microarray platform that enables multiplex testing at an affordable cost.

Vibrant’s relationship with its patients and providers is special. We go out of our way to provide the value and resources our providers need to accurately interpret test results and give patients the most accurate health information.

The Most Accurate In the Industry

All tests run on Vibrant’s proprietary 3Dense microchip technology platform boast an unrivaled specificity and sensitivity – which translates to the highest standard of accuracy of results in the lab industry.

Our Lab Technology

Vibrant America is at the forefront of modern medicine. Our technology was developed out of passion for better medicine, and we believe that automation is the key to high-quality and accurate test results. Multiplexing tests on a single sample enable a fast turnaround time.

Our Mission

Dedicated to bring clinically relevant test at a rapid pace to enable affordable high-quality diagnostics to every individual.

  • High-quality lab service
  • Fully automated systems
  • Low cost
  • Fast Turn Around Time

Quality and Security

All of our laboratory testings is done in a CLIA and CAP-certified laboratory in California.

Vibrant America's Compliance Overview

FAQ

If this test is negative but I still have the symptoms, is it possible that I might still have SIBO?

IBSSureTM measures two blood-based antibodies that can be used in the diagnostic workup of IBS, and to rule out IBD. These antibodies can also identify past exposure to bacterial toxin (food poisoning), and autoimmunity of the intestinal motility system (pacemaker cells in the GI tract). Finally, anti-CdtB antibody has been correlated with positive SIBO diagnosis. It is still possible to have the signs and symptoms of SIBO without having a positive result on this test.

If this test is capturing an infectious gastroenteritis event, how many years back would the event be accounted for?

A systematic review and meta-analysis found that more than 10% of individuals with infectious enteritis later develop IBS. The overall risk of developing IBS is 4.2 times higher in individuals with a history of infectious enteritis versus individuals without a history of infectious enteritis. The prevalence of IBS at 12 months after infectious enteritis was 10.1% and at more than 12 months after infectious enteritis was 14.5%. Studies have examined post-infectious IBS onset within 12 months, within 13-59 months, and greater than 60 months (5 years) after the infectious event. Prevalence of post-infectious IBS depends upon the pathogen(s) involved, geographic location, clinically suspected or laboratory-proven enteritis, time of medical assessment following the infectious enteritis, and the criteria used to define IBS. Some studies report a decline in prevalence of IBS over time since the infectious event, whereas others report an increase in prevalence of IBS over time since the infectious event. It is unknown how long CdtB antibodies and vinculin antibodies will persist after an infectious enteritis.

Does positive anti-vinculin indicate an autoimmune condition?

Yes, because the body is producing antibodies to the vinculin protein located in the migrating motor complex (MMC), therefore, antibodies to its own tissues.

What does IBS-M mean?

IBS-M means Irritable Bowel Syndrome – Mixed, which means the patient experiences a combination of constipation and diarrhea.

I was told that this is not a SIBO test. What is IBSSure testing?

Vibrant’s IBSSureTM is a simple, gut-motility test that can be used to identify irritable bowel syndrome (IBS), and to rule out inflammatory bowel disease (IBD). We identify two markers: CdtB (Cytolethal Distending Toxin B) and anti-vinculin, which confirms dysmotility at the junction of the large and small intestine; this could present itself symptomatically as diarrhea or constipation. The importance of understanding the migrating motor complex (MMC) can help alleviate your patient’s symptoms. Should both biomarkers be elevated, there is an 89% correlation to SIBO. Simple intervention of a prokinetic supplementation and lifestyle changes that will stimulate the MMC could provide your patient with symptomatic alleviation.

How It Works

1

Order your test

You'll get an email confirmation from us.

2

Within 48 hours of payment

The lab will confirm your order and provide tracking.

3

2 days after kits ship

We will send you test instructions.

4

When results are in

You'll be notified via email, with instructions to access via secured portal.

5

Interpretation

Learn how to read your lab report.

*Please read the following prior to placing your lab test order*

  • All sales are final and no refunds will be afforded and you waive any rights to charge-back your purchase with your credit card processor.
  • Vibrant does not participate in, take assignment, or accept any private insurance. We do not provide super bills and cannot assist with claim resolution for laboratory tests or consultations.
  • Orders for this test are accepted from the United States only.
  • Vibrant is unable to ship test kits to the state of New York as per state laws.
  • Vibrant is unable to ship lab kits to P.O. boxes. Please use a residential or business address.
  • After you order a test kit, getting the lab draw and/or completing the test is your responsibility.
  • Once Vibrant has received your test results, the results will be uploaded to your HIPAA compliant client portal and you will receive an email instructing you how to access them.
  • All Vibrant tests are done at Vibrant America Clinical Labs.
  • You will receive a link with follow up instructions after your order is completed.

Before Placing Your Order Please Read
The Complete Terms and Conditions for Vibrant Test Orders

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

*Regulatory Statement*
Vibrant testing does not demonstrate absolute positive and negative predictive values for any disease state or condition. Its clinical utility has not been fully established. Vibrant validates the accuracy and precision of the testing but not of its clinical or diagnostic value. So these tests are for wellness and informational purpose only. Vibrant is actively doing clinical research on these samples, de-identified from patients under an IRB and will make research publications towards the same as and when the clinical utility is well established. These tests have been laboratory developed and their performance characteristics determined by Vibrant America LLC, a CLIA-certified laboratory performing the test CLIA#:05D2078809. The test has not been cleared or approved by the U.S. Food and Drug Administration (FDA). Although FDA does not currently clear or approve laboratory-developed tests in the U.S., certification of the laboratory is required under CLIA to ensure the quality and validity of the tests. The general wellness test intended uses relate to sustaining or offering general improvement to functions associated with a general state of health while making reference to diseases or conditions. Content provided for informational purposes only and should not be construed as medical advice. Content provided to help you make a healthy lifestyle, dietary, and treatment choices in consultation with your healthcare provider. It is intended to be used as a tool to encourage a general state of health and well-being. Please consult with your healthcare practitioner for diagnosis and treatment considerations. The Vibrant Wellness platform provides tools for you to track and analyze your general wellness profile.